John W Prineas (1937-present)

By the middle of this century, a great deal was known about the pathological changes that occur in MS, and the clinical effects of those changes, but the underlying mechanisms leading to tissue pathology were poorly understood, although an immunological role had been confirmed.

During the 1970s and 1980s, John. Prineas of New Jersey, USA used specialised light and electron microscopy techniques to examine the detailed histology of MS lesions, providing clues about their pathogenesis (16).

The slide shows one of Prineas's electron microscopy images showing a microglial cell (arrow) and macrophage in the vicinity of demyelinating axons (16).

It had already been shown that MS lesions contain lymphocytes and plasma cells, suggesting the existence of a local immune response to an unknown antigen, but Prineas's observations led him to conclude that both macrophages and microglial cells are required for the digestion of myelin. Prineas's studies also suggest that within chronic lesions there is a continued expression and processing of antigen in the absence of fresh lesion formation (16).

==> Ian R Young (1932-present)

Latest News

More news

What's hot


Kiss Goodbye to MS...

is a campaign about hope, that together we can raise funds to accelerate Irish and global research into MS and continue to provide services to over 9000 people living with MS In Ireland. Join the campaign NOW!

Find out more

Events Calendar

» Our next Event

27 May 2019: Yoga Classes for People with MS Payment to be made on the first class of a new block of classes to a desig...

View all events


If you'd like to receive e-news updates from The Society please enter your email address below. If you want to know more about how we manage personal data then please see our privacy policy.

My local MSI

Map of MS Ireland's service areas South Mid West West Midlands South East North East North West North Dublin City and Fingal South West Dublin and Kildare South East Dublin and Wicklow